We also looked at the ability of disseminating granulomas to achieve sterilization under these conditions and found at 400 days PI the baseline dissemination granulomas become sterile 3% of the time, IL-10 depletion leads to sterilization in 5% of granulomas, and the TGF-β1 depletion leads to sterilizing immunity in 29% of granulomas, while the double depletion leads to sterilization in 24% of granulomas (Figure 6F). This evidence concerns the gene TGFB1 and Granuloma.