For instance, expressions of programmed cell death 1 ligand 1 (PD-L1) and PD-1 were reportedly upregulated in mice with sepsis/multiple organ dysfunction syndrome (MODS) and were closely related to tolerant DCs and development of MODS, as blockade PD-L1 and PD-1 signaling significantly reversed above disadvantages (82). Here, CD274 is linked to Sepsis.