Moreover, the inhibition or impairment of ATG16L1 was associated with autophagy block and incapacity to control inflammasome proteolysis in autophagolysosomes resulting in exacerbated IL-1β secretion, inflammation and necrotic cell death in the context of epithelial cells and Crohn’s disease (26, 45). The gene discussed is ATG16L1; the disease is Crohn disease.