The study demonstrated that the TRUS biopsy detected cancer in 32 versus 60% with TPTP, and that TPTPB is associated with a significantly higher prostate cancer detection rate than TRUS biopsies in biopsy naïve men with PSA <20 ng ml−1 and a benign feeling DRE (13). Here, KLK3 is linked to Familial prostate cancer.