However, there are also some drawbacks which the investigators encountered during the MSC-researches; it was found that stromal cells, pericytes, and endothelial cells exert a supportive role in tumor growth and progression by producing several growth factors such as TGF-β, PDGF, EGF, VEGF-A, and IL-8 (5, 6). This evidence concerns the gene TGFB1 and neoplasm.