The strategies applied for the anticancer genes/agents delivery are based on the following principles (1) (Figure 1): (1) Augmentation gene therapy which includes: (a) expressing a gene to prompt apoptosis (e.g., TRAIL, mda-7, Caspases and selective short interfering RNA (siRNA)/microRNA (miRNA)-mediated blocking of anti-apoptotic genes), (b) improving tumor sensitivity to chemo/radiation therapy, (c) introducing a tumor suppressor gene (e.g., P53, Rb, p16INK/CDKN2, and PTEN). This evidence concerns the gene TNFSF10 and neoplasm.