PI3Ks modulate oxidative stress and insulin resistance via the DHA Signaling (network 1) (20) and the Insulin Receptor Signaling (network 2) pathways and the Jnk domain (network 1) and is highlighted by significant scoring of the Type II Diabetes Mellitus Signaling pathway (network 5). The gene discussed is INSR; the disease is type 2 diabetes mellitus.