Subjects with prediabetes showed an increase in LC3-II and LAMP-2 mRNA expression which is consistent with the observations of Llopis et al. (28) who demonstrated augmented LC3-II protein expression in T2DM patients with HbA1C 6.8% (50.8 mmol/mol) similar to prediabetic subjects in our study with HbA1C 6% (42.1 mmol/mol). The gene discussed is LAMP2; the disease is type 2 diabetes mellitus.