PRKN and diabetes mellitus: However, in patients with diabetes, a significant and negative correlation was observed between rising HbA1C levels and mitophagy markers including PINK1 (r = −0.739; p < 0.01), MFN2 (r = −0.734; p < 0.01), NIX (r = −0.806, p < 0.01), PARKIN (r = −0.730; p < 0.01), LC3II (r = −0.709; p < 0.01), and LAMP2 (r = −0.896, p < 0.01).