In subjects with prediabetes, MFN2 (r = 0.558; p < 0.01), PINK1 (r = 0.534; p < 0.01), NIX (r = 0.637; p < 0.01) and LC3-II (r = 0.667; p < 0.01) mRNA expression was significantly and positively correlated with the HbA1C levels. This evidence concerns the gene MFN2 and prediabetes syndrome.