PINK1 and diabetes mellitus: However, in patients with diabetes, a significant and negative correlation was observed between HbA1C levels and mitophagy-related genes including PINK1 (r = −0.563; p < 0.01), MFN2 (r = −0.651; p < 0.01), NIX (r = −0.581, p < 0.01), PARKIN (r = −0.518; p < 0.01), LC3-II (r = −0.665; p < 0.01), and LAMP-2 (r = −0.744, p < 0.01).