The follicular cells of the thyroid gland require the PAX8 gene, and the rearrangement of PAX8 might be related to thyroid tumors, which is in accordance with the representation of the pathway that PAX8 was mainly involved in thyroid hormone synthesis and thyroid cancer pathways (Mansouri et al., 1998; Nikiforova, 2003). This evidence concerns the gene PAX8 and thyroid gland carcinoma.