Aberrant regulations of the Akt-mTOR-survivin and the p53/Sp1-survivin signaling pathways have widely been shown to promote the survival of cancer cells and the induction of anti-cancer drugs resistance (Cheung et al., 2009; Coumar et al., 2013; Dong et al., 2014; Sun et al., 2014; Han et al., 2015; Parvani et al., 2015; Kim et al., 2016). This evidence concerns the gene SP1 and cancer.