ADORA1 and Alzheimer disease: Indeed, various factors increasing the metabolism such as an increase in neuronal activity caused by adenosine A1 receptor antagonists, blockers of GABA(A) receptors and potassium channels (Dzhala et al., 2000), elevation of extracellular potassium as in the present study or elevated temperature (Joshi and Andrew, 2001) strongly accelerate the AD onset.