In fact, a cell-penetrating peptide based on this interacting region, TAT-Cx43266–283, is sufficient to recruit c-Src, CSK and PTEN and to inhibit c-Src activity in different types of glioma cells (Gangoso et al., 2014; González-Sánchez et al., 2016; Jaraíz-Rodríguez et al., 2017). Here, PTEN is linked to central nervous system cancer.