We have recently shown that Cx43, through the interaction with c-Src and its endogenous inhibitors c-terminal Src kinase (CSK) and phosphatase and tensin homolog (PTEN), inhibits c-Src activity in astrocytes and glioma cells (Herrero-González et al., 2010; González-Sánchez et al., 2016; Tabernero et al., 2016). Here, CSK is linked to central nervous system cancer.