Thus, the deleterious contribution of c-Src activity to neurodegeneration have been extensively documented in models of Parkinson’s disease (Tai et al., 2013; Wang et al., 2016), Alzheimer’s disease (Dhawan and Combs, 2012; Kaufman et al., 2015) and stroke (Paul et al., 2001). The gene discussed is SRC; the disease is early-onset autosomal dominant Alzheimer disease.