Although neuroprogenitors could be generated without any problem, the generation of “COUP-TF-interacting protein 2” (CTIP2), forkhead box protein P2 or “T-box, brain, 1” (TBR1) positive cortical neurons was dramatically lower in FTD patient lines compared to lines from their normal family members. The gene discussed is TBR1; the disease is frontotemporal dementia.