TF and leukemia: To study the different HM patterns surrounding TF BSs and non-BSs and the conservation of these patterns, we downloaded data from the ENCODE Consortium (Supplemental Table S1; http://genome.ucsc.edu/ENCODE/downloads.html) for three human cell lines: B-lymphoblastoid cells (GM12878), erythrocytic leukemia cells (K562), and embryonic stem cells (H1-hESC).