DNMT3A and leukemia: For instance, DNMT3A mutations are associated with a specific DNA hypomethylation pattern in acute myeloid leukemia (Russler-Germain et al. 2014), and loss of DNMT3A leads to hypomethylation of hematopoietic enhancers in FLT3-ITD–associated leukemias (Yang et al. 2016).