Further, the higher proportion of hypomethylation in naïve B cells is consistent with observations of hypomethylation in DNMT3A-mutant and Dnmt3a-null leukemias (Haney et al. 2016a,b; Russler-Germain et al. 2014; Yang et al. 2016). The gene discussed is DNMT3A; the disease is leukemia.