Furthermore, upon examination of associations with terms of the Disease Ontology, a standardized ontology for human disease, putative target genes of Dnmt3a-dependent hypomethylated DMRs were found to be enriched for genes involved in lymphoblastic leukemia, a term including the B cell malignancy, CLL (Figure 4B). The gene discussed is DNMT3A; the disease is acute lymphoblastic leukemia.