IFIH1 and clinically amyopathic dermatomyositis: As several lines of study suggest, potent immunosuppressive combination therapy using high-dose glucocorticoid, calcineurin inhibitors, and cyclophosphamide should be considered as induction therapy for acute progressive ILD, particularly in patients with CADM who are positive for anti-MDA5 Ab, because of unfavorable prognosis, as mentioned above [30].