In 2006, important genetic studies in Drosophila melanogaster stemming from the original Parkin mutant fly discovery [2] suggested that PINK1 shares a common pathway with the E3 ubiquitin ligase Parkin, another autosomal recessive gene product of PD, where Parkin apparently functions downstream of PINK1 [3, 4]. This evidence concerns the gene PRKN and Parkinson disease.