CASR and Hypercalcemia: In addition, our results reveal that some individuals who are heterozygous for the AP2σ Arg15His may be normocalcaemic and this is similar to the reports that heterozygous loss-of-function CaSR mutations, which are associated with hypercalcaemia in the majority of patients may also rarely be associated with normocalcaemia in some individuals (33,34).