Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia [fasting plasma glucose ≥126 mg/dl (7.0 mmol/l) or 2-h plasma glucose ≥200 mg/dl (11.1 mmol/l)] resulting from defects in insulin secretion, insulin action, or both [1]. The gene discussed is INS; the disease is Other metabolic disease.