PIK3CA and cancer: Indeed, A3-mediated host genome destabilization may be one of the mechanisms that drive carcinogenic progression of HR-HPV–associated lesions as evidenced by Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) mutations that are consistent with A3 mutagenesis that have been detected in HPV-associated cancers [17].