Interestingly, myeloid Fizz1/Relmα expression, which was substantially decreased in Klf4(f/f);Lys-Cre tumor myeloid cells, was shown to promote collagen-cross linking, increase collagen fibril density and facilitate wound healing in a model of cutaneous injury [42], further suggesting presence of low-density collagen fibers in Hi-Myc PCa tumors in Klf4(f/f);Lys-Cre recipients. Here, KLF4 is linked to posterior cortical atrophy.