This suggests that deletion of Klf4 influences specific aspects of M1 differentiation and represses others in the Hi-Myc PCa microenvironment and perhaps less than that seen upon culture of Klf4(f/f) versus Klf4(f/f);Lys-Cre BMDM in IFNγ (M1 inducer) or IL-4 (M2 inducer) [19]. Here, KLF4 is linked to posterior cortical atrophy.