CD8A and posterior cortical atrophy: Klf4(f/f) and Klf4(f/f);Lys-Cre mice received 4 doses of CD8 antibody 7, 5, 3 and 0 days prior to PCa cell implantation, and depletion was confirmed by FC analysis of peripheral blood 1 day prior to implantation (Fig 6A and 6B).