Analyzing cancer genomes from seven rare types of metastatic adolescent and young adult cancers (including ONB) using whole exome sequencing [WES], whole-transcriptome sequencing, or OncoScanTM, Cha et al. identified TP53 missense mutation in a metastatic ONB sample, as well as a loss-of-function in CDKN2C gene [14]. Here, CDKN2C is linked to cancer.