Ceruloplasmin (CP) was first isolated from plasma and characterized by Holmberg and Laurell in 1948 as a copper-containing protein.[1] Soon thereafter, Scheinberg and Gitlin demonstrated a marked decrease in the concentration of this protein in serum samples from patients with Wilson’s disease (WD).[2] Serum CP level measurement is the first step in screening for WD. This evidence concerns the gene PROS1 and Wilson disease.