After adjustment for variables tested as significant in multivariate models, being registered before/in 2007 (OR = 2.10 [95%Cl:1.24–3.56]), not being infected through homosexual mode (2.05 [1.18–3.56]), female gender (2.14 [1.33–3.44]) were increasing and higher nadir lymphocyte CD4+ count (0.92 [0.85–0.99]) decreasing the odds of first urinary tract infection. The gene discussed is CD4; the disease is urinary tract infection.