These data support the conclusion that both type I IFNs and IFN-γ specifically imprint the ISG expression pattern during both phases of infection (type I-ISGs and type II-ISGs, respectively) and suggest that convergence of type I and type II IFNs is important during both phases of pathogenic SIV infection for sustained expression of the large set of type I&II ISGs at higher levels than either type I or type II-ISGs. Here, IFNG is linked to infection.