In summary, the present study discovered that c-Src contributed to hypoxic microenvironment-rendered paclitaxel resistance in human epithelial ovarian cancer cells by G2/M phase arrest deterioration, and through c-Src suppression, FV-429 was capable of reversing the resistance by blocking the c-Src/Stat3/HIF-1α pathway. Here, HIF1A is linked to ovarian carcinoma.