As shown in Figure 6d, after FV-429 treatment, the protein expression ratios of p-Src/c-Src and p-Stat3/Stat3 and HIF-1α expression decreased in hypoxic tumor tissues (the central part of tumors and normoxic tumor tissues referred to the outer part of tumors21), and IHC study (Figure 6e) showed the expression of c-Src and HIF-1α and nuclear translocation of Stat3 decreased in the tissues. Here, HIF1A is linked to neoplasm.