ATP and its metabolite, adenosine, are major constituents of tumor microenvironment and may differently affect tumor growth, immune cells and tumor-host interaction by activating a wealth of metabotropic (i.e., P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14) and ionotropic (P2X1–2X8,) receptors [122]. The gene discussed is P2RY2; the disease is neoplasm.