However, NHE-1 blockers, including cariporide and the more specific 3-methyl-4-flouro analog of 5-aryl-4(4-(5-methyl-14-imidazol-4-yl) piperidin-1-yl)pyrimidine (Compound 9t), have been put forward as alternative anti-cancer drugs [195]. The gene discussed is SLC9A1; the disease is cancer.