Transcriptomic and metabolomic analyses of mutant Drosophila deficient for the mitochondrial serine/threonine‐protein kinase PTEN‐induced putative kinase 1 (PINK1), a model of PD, showed that PINK1 deficiency leads to alterations in nucleotide metabolism, suggesting that enhancing nucleotide biosynthetic pathways could be a strategy to reverse mitochondrial dysfunction in PD 48. Here, PINK1 is linked to Parkinson disease.