Also, the frequencies of the CR1 genotypes rs17047661AG and rs17047661GG (p = 0.015, OR 3.0, 95%CI 1.25-7.49) and rs6691117AG and rs6691117GG (p = 0.004, OR 2.2, 95%CI 1.26-3.53) were significantly higher in chronic CD patients than in controls (Table 1). The gene discussed is CR1; the disease is Cowden disease.