CAV1 and Central diabetes insipidus: A recent study in vasopressin-deficient Brattleboro rats with central diabetes insipidus (DI) proposed a role for Cav1 in the urinary concentration process; stimulation of DI rats with the vasopressin V2 receptor agonist desmopressin (dDAVP) induced a sustained apical translocation of Cav1 in principal cells of collecting ducts14.