INSR and breast cancer: Combining all the top-ranked enriched signaling pathways (P value < 0.01) from IPA and the MCF7-related pathways widely reported in previous literatures, we manually constructed a generic pathway map (see Fig. 2) that includes important signaling pathways in breast cancer cells, such as ER/SHC pathway [13], EGFR signaling [14], HER2 signaling [15], INSR pathway [16], and HDAC pathway [16] et al. For example, several evidences proved the interplay between BRCA1 and cell cycle regulation.