The results showed that total pro‐MMP‐1 protein expression (Fig. 2C) and its corresponding MMP‐1 activity (Fig. 2D) were higher in MSCs with greater tumor‐tropic potential in comparison with the poorly migrating MSCs, suggesting possible crosstalk between MMP‐1 and IGF‐2 signaling. This evidence concerns the gene IGF2 and neoplasm.