CRP and obesity due to melanocortin 4 receptor deficiency: Disease-causing obesity, hyperglycaemia, atherogenic dyslipidemia, endothelial dysfunction, and stimulation of vasoconstrictor systems in MS are believed to be associated with renal impairment by systemic release of glycated products, free radicals, and some pro-inflammatory mediators, such as uric acid (UA) and C-reactive protein (CRP) [5-7].