The accumulation of excess lipids in fatty tissue in obesity leads to adipocyte dysfunction, hypoxia, oxidative stress, and chronic inflammation, accompanied by the release of proinflammatory and diabetogenic cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL6), etc. [22]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.