In malignant tumors compared to Low Malignant Potential (LMP) tumors in GSE9899 dataset, AKT3 is downregulated by 2.1 folds (p-value < 0.0012); PTTG1, MND1, and CENPF are upregulated with 5.9 (p-value < 2.83 E-19), 4.12 (p-value 9.9 E-11), and 3.17 folds (p-value < 1.67E- 08), respectively. The gene discussed is PTTG1; the disease is cancer.