These receptors seem to act by triggering the PI3K/Akt pathway activation, which in turn results in the upregulation of the levels of anti-apoptotic protein BCL2 and X-linked inhibitor of apoptosis protein (XIAP), which mediate resistance to anoikis and survival of tumor cells in circulation; see Figure 1 [3, 4]. The gene discussed is AKT1; the disease is neoplasm.