The glycolipids in Schistosoma mansoni (Sm) adult worm, the C-type lectin DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and TLR4 on DCs have crucial roles in DC activation, which can skew the T cell response toward a Th1 profile during the early stage of a Sm infection (16). This evidence concerns the gene TLR4 and infection.