VTCN1 and systemic lupus erythematosus: While our data show that B7-H4 deficiency or B7-H4 antagonist antibody 6H3 could aggravate the BMDCs-ALD-DNA lupus model, a potential approach to inhibit the progression of lupus is by regulating B7-H4 expression in the form of an agonist of the unknown receptor (53).