We examined the components of the inflammatory cells in the lupus mice and found that the percentages of CD4+ T, IL-2+, IL-17+ cells in peripheral blood were significantly higher in B7-H4-KO BMDCs-ALD-DNA induced lupus mice than that in WT BMDCs-ALD-DNA induced lupus mice (Figure S2B in Supplementary Material). This evidence concerns the gene CD4 and systemic lupus erythematosus.