Since exacerbation of the lupus syndrome in the B7-H4-deficient BMDCs-ALD-DNA induced model can be abolished by CD4+ T cell depletion in vivo (Figure 2F), thus this suggests that the B7-H4 signal mainly affects CD4+ T cell function to affect lupus disease manifestations. The gene discussed is VTCN1; the disease is systemic lupus erythematosus.