In this study, we raised a new method of inducing the mice SLE model, by transferring bone marrow-derived dendritic cells (BMDCs) that incubated with ALD-DNA to mice through tail vein, and using this model explored the potential role of B7-H4 in SLE disease progression by blocking or increasing B7-H4 expression. Here, VTCN1 is linked to systemic lupus erythematosus.