Conversely, the anti-inflammation cells CD4+Foxp3+ Treg cells (Figure S2C in Supplementary Material) were significantly lower in B7-H4-KO BMDCs-induced lupus mice compared to control mice; thus, these results show that the lack of B7-H4 on DCs has changed the balance between T effector and Treg cells in this model. This evidence concerns the gene FOXP3 and systemic lupus erythematosus.