VTCN1 and systemic lupus erythematosus: As B7-H4-deficient mice do not show autoimmunity (56), B7-H4 signal deficiency markedly accelerates the development of lupus in a DC-induced lupus model, suggesting that the B7-H4 signal is crucial in the pathogenic condition and alleviates the BMDCs-ALD-DNA induced lupus progression.