The effect of 6H3 in the BMDCs-ALD-DNA induced lupus model was diminished by CD4+ T cell depletion (Figure 3G), in accordance with B7-H4-KO-BMDCs-ALD-DNA-induced sever lupus mice syndrome dependent on CD4+ T cells (Figure 2F). This evidence concerns the gene CD4 and systemic lupus erythematosus.