Surprisingly, however, PFKFB3 haplodeficiency or the treatment with a low dose of 3PO, which target the hyperglycolytic tumor ECs (but not the cancer cells), do not affect tumor growth but instead exert a favorable effect on tumor vessel normalization, characterized by remodeling of the tumor vasculature into a more normal one, with a tighter vascular barrier, more pericyte coverage (vessel maturation), and improved vessel perfusion and oxygenation. The gene discussed is PFKFB3; the disease is neoplasm.