Ongoing work is currently in progress to further compare other neurological diseases involving progressive synaptic disorganization and intellectual disability, including attention deficit hyperactivity disorder, epilepsy, prion disease and others for Shank3 deficits, and how different “loss-of-function” mutations or altered Shank3 expression can lead to such phenotypic diversity. This evidence concerns the gene SHANK3 and attention deficit-hyperactivity disorder.