SHANK3 and familial Alzheimer disease: Here, we report the common downregulation in the expression of Shank3 in sporadic AD, ASD, BD, PMS, and SZ in 7-month-old 5x familial Alzheimer’s disease (5xFAD) transgenic animals exhibiting extensive amyloid deposition, compared with age-matched controls and in stressed human neuronal–glial (HNG) cell cocultures (see below; Figures 1 and 2).