FOS and schizophrenia: Given the potential role of this IEG in schizophrenia pathophysiology and treatment, it is to mention that early studies have also compared Egr1 modulation by antipsychotics to the modulation of the other well-known IEG c-fos, showing that these two IEGs, although similarly impacted by typical and atypical antipsychotics in cortex and striatum, displayed some substantial differences.