BDNF and schizophrenia: Starting from the assumption that antipsychotic treatment could be correlated to neurotrophic actions in brain areas affected in schizophrenia, Angelucci et al. (2000) reported that chronic treatment with haloperidol or risperidone may decrease BDNF expression in hippocampus, frontal and occipital cortices, also affecting TrkB expression in these areas.