Egr1 synaptic action has been related to neural plasticity, in particular to synaptic processes leading to memory consolidation and behavioral adaptations (Davis et al., 2003; Okada et al., 2015) Intriguingly, dysfunctions in the postsynaptic machinery deputed to control memory and learning processes have been recently related to cognitive impairment in major neuropsychiatric disorders, such as schizophrenia (Grant, 2012). The gene discussed is EGR1; the disease is schizophrenia.