Further proteomic profile analysis showed that higher expression of surface-related proteins (FnbpA, SpA, Atl, ClfA, IsaA, IsaB, LtaS, SsaA and Cna) may involve in the durative infection in HA-SA ST239, while the higher expression of Agr system (AgrA and AgrC) and its interactive factors (PhoP, SrrB, YycG, SarX, SigB and ClpP) contribute to the higher virulence in CA-ST ST398. This evidence concerns the gene CLPP and infection.