Taken together, biologically, we could conclude that the higher expression of Agr system and its interactive factors (PhoP, SrrB, YycG, SarX, SigB and ClpP) based on the protein-protein interaction network in the CA-SA ST398 strains may improve the acute infection of CA-SA, while the higher expression of agr-negative regulating surface-related factors (FnbpA, SpA, Atl, ClfA, IsaA, IsaB, LtaS, SsaA and Cna) contribute to the durative infection of HA-SA. This evidence concerns the gene CLPP and infection.