Anti-tumor and anti-angiogenic activities of SB extracts in LoVo and human umbilical vein endothelial cells are partially mediated by the inhibition of Akt/protein kinase B. This inhibition was Akt kinase-specific, as it had no effect on PI3K, the upstream kinase of Akt, whereas the levels of phosphorylated Bad and FHKR, the two downstream targets of Akt, changed as the levels of Akt changed [55]. This evidence concerns the gene AKT1 and neoplasm.