ADIPOQ and type 2 diabetes mellitus: In the current study, we not only observed the inverse association in a Chinese population after comprehensive adjustment, but also conducted an updated meta-analysis with a much larger sample size (7504 incident T2D cases and 64,696 participants), which provided strong evidence for the role of adiponectin in the pathogenesis of T2D across diverse populations, a consistent finding despite methodologic variations such as adiponectin assays, diagnostic criteria for T2D and follow-up durations.