A previous meta-analysis of 13 prospective studies (2623 incident T2D cases and 14,598 participants) reported an inverse association between adiponectin levels and T2D risk (RR 0.72 for per 1-log μg/mL increment in adiponectin levels) across different populations5, but no study was done in Chinese population. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.