In addition, impairment of E/I balance has also been found in APP-overexpressed AD mouse models50,51 and in in vitro Aβ exposure50. Moreover, the decreased level of the interneuron specific PV cell-predominant voltage-gated sodium channel subunit Nav1.1 leads to decreased inhibitory synaptic activity and enhanced hypersynchrony, memory deficits and premature mortality51. This evidence concerns the gene APP and Alzheimer disease.