By IHC, we found Gli1 was positively expressed in 17 out of 20 HER2 positive tumor tissues, while in 28 out of 47 HER2 negative tumors tissues, fourfold table chi-square test showed the expression level of Gli1 and HER2 was related (P = 0.043, Table 1). The gene discussed is ERBB2; the disease is neoplasm.