IFNA1 and acquired polycythemia vera: Furthermore, neither IFN-α nor ruxolutinib induces morphologic or cytogenetic remission in PV or has been shown to alter the natural history of the disease; of note, the clinical relevance of IFN-α-induced suppression of JAK2V617F allele burden, which is seen in a small minority of patients47, and also documented with busulfan therapy51, is unclear.