Figure 4A (CRC) and 4B (LA) show the Kaplan–Meier curves for the combination of SHMT2 with MTHFD2. Patients with high expressions of SHMT2 and MTHFD2 had worse prognoses compared to those with the other expression patterns of the enzymes in CRC (p = 0.030) and LA (p < 0.002). This evidence concerns the gene MTHFD2 and colorectal carcinoma.