Given that the concept of “BRCAness” was primarily introduced in BRCA1/2-deficient epithelial cancers, further mechanistic evaluation of the HRR pathway and, most importantly, genomics-guided clinical trials in LMS patients will be necessary to formally establish whether a “BRCAness” phenotype confers sensitivity to these drugs as in breast, ovarian, and prostate cancer. The gene discussed is BRCA1; the disease is prostate cancer.