RB1 and cancer: Furthermore, multiple cancer drivers as well as components of the CINSARC prognostic gene expression signature12 were affected by CNAs in at least 30% of cases, including genes encoding tumor suppressors (PTEN, RB1, TP53), DNA repair proteins (BRCA2, ATM), chromatin modifiers (RBL2, DNMT3A, KAT6B), cytokine receptors (ALK, FGFR2, FLT3, LIFR), and transcriptional regulators (PAX3, FOXO1, CDX2, SUFU) (Fig. 2a).