The increase in the number of fibroblast-like cells expressing FSP in our study following TGFβ1 stimulation of lung tissue is therefore consistent with previous observations from IPF tissue, while the ability of senicapoc to inhibit this is consistent with its ability to inhibit the proliferation and differentiation of primary human lung myofibroblasts20. The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.