These bNAbs target different epitopes on the HIV-1 envelope (Env) protein, including the CD4-binding site (26, 27), the V1/V2 and V3 glycan loops (28, 29), and the interface of gp120 and gp41 (30), and several bNAbs are being explored for the prevention and treatment of HIV-1 infection (1, 2, 31). Here, ITIH4 is linked to HIV-1 infection.