DAXX/ATRX mutations also confirmed their value as predictor of poor prognosis: subjects bearing tumours with inactive DAXX/ATRX had a lower disease-specific survival, as also outlined by another recent study on 321 PanNET patients that reported an association between ALT-positive, DAXX/ATRX-negative PanNETs and shorter disease-free survival (Singhi et al. 2017). Here, ATRX is linked to neoplasm.